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In recent years, AMPK has emerged as a desirable target for modulation of numerous diseases, yet clinical therapies remain elusive.
In animals, Mediator has been implicated in the control of differentiation and morphogenesis through modulation of numerous signaling pathways.
It spans a complex network of pathways, ranging from DNA repair to modulation of numerous processes in the cell.
In addition to its ability to induce the release of neuropeptides from sensory neurons, TRPA1 seems to play an important role in the modulation of numerous genes that could amplify the cutaneous inflammatory process.
Shosaiko-to, a Japanese herb, possesses many ethopharmacological effects, such as the modulation of numerous host immune responses.
microRNAs (miRNAs) have been found to play an essential role in the modulation of numerous biological processes in eukaryotes.
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EMT is a complex multistage process that includes morphological changes accompanied by modulation of the expression of numerous proteins, in particular cytoskeletal and adhesion molecules [ 42].
Since other studies have shown that pH modulation could regulate expression of numerous tumor enzymes [ 5], we investigated the in vivo expression of carbonic anhydrase IX (CAIX) in mice treated with sodium bicarbonate.
Although we cannot rule out the possibility that minor changes in the detected metabolite profiles resulted from degradation of compounds in the fungal hydrolysate, dynamic and substantial modulations in the levels of numerous metabolites strongly supports genuine and profound changes in the plant cell metabolome.
Evidence suggests that modulation of nAChRs may benefit numerous CNS and peripheral nervous system (PNS) disorders.
The stabilization of Nrf2 is believed to involve modulation of some of the numerous cysteine residues of Keap1 by ROS and electrophiles, leading to enhanced Nrf2 stability and nuclear accumulation [20 22].
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