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Exact(5)
These associations appeared driven by genes involved in editing/processing nucleases, modulation of nucleotide pools, and nucleotide excision repair.
Specifically, we found that genes within nucleotide excision repair (which includes GTF2H4) and modulation of nucleotide pools (which includes DUT) to be associated with HPV persistence.
Thus, it is possible that subtle modulation of nucleotide sequence may also serve to regulate protein structure and function, and such sequence may have experienced evolutionary pressure to produce fully functional proteins.
Therefore, modulation of nucleotide metabolism might be beneficial for nDNA maintenance in the context of replication stress conditions, which reduce dNTP availability (Lopez-Contreras et al, 2015).
Nonetheless, given the expected proximities of the N-terminus, helix Sα1, and C-terminal sequences of the RS domain within the N-lobe, RS2 may associate with the NRF and provide a direct route for SR protein phosphorylation enhancement through the modulation of nucleotide exchange rates.
Similar(55)
However, they also exert an additional indirect inhibitory effect via modulation of nucleotide-dependent channel gating.
Expression profiles of defense-related genes showed a dynamic modulation of nucleotide-binding site-leucine-rich repeat (NBS-LRR) resistance genes and pathogenesis-related (PR) genes during berry development.
Tian et al. [36] recently demonstrated a novel protective mechanism of ANP against pathologic hyper-permeability and suggested a pharmacological intervention for the prevention of increased vascular leak via PAK1-dependent modulation of guanine nucleotide exchange factor H1 activity.
The barcoding strategy is similar to RAD but modulation of barcode nucleotide composition and length results in fewer sequence phasing errors.
The ER location of AtCYP19-4 (CYP5) has been confirmed by N-terminal green fluorescent protein fusion, and may involve the modulation of a guanine nucleotide exchange factor essential for vesicle trafficking [ 48, 49].
Other mechanisms may involve modulation of Rho-specific guanosine nucleotide exchange factors (GEFs) by signal protein kinases (PKA, PKC, and Src) activated by OxPAPC [ 66, 68].
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