Sentence examples for modulation of nuclear from inspiring English sources
Our data highlight a new mechanism controlling TFEB subcellular localization and activity via the modulation of nuclear export.
We found that TFEB continuously shuttles between the cytosol and the nucleus and that the nutrient-dependent modulation of nuclear export rates plays a major role in controlling TFEB subcellular localization.
Functioning as transcription factors and thereby controlling cellular processes at the level of gene expression, modulation of nuclear receptor activity produces selective alterations in downstream gene expression.
Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics.
Modulation of nuclear factor-kappa B (NF-κB) activation in monocytes and regulation of the oxidative stress response through nicotinamide adenine dinucleotide phosphate (NADPH) signaling appear to be key targets in modulating this response.
These experiments suggested that ibudilast inhibits Tat-mediated transcription of TNFα via modulation of nuclear factor-kappa B (NF-κB) signaling.
Huang, R. et al. Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.
However, whether mTOR directly phosphorylates TFEB in the nucleus or if other kinases are involved in the modulation of TFEB nuclear export requires further investigation.
Moreover, the observation that the liver was the main target for ERRα inhibition by pharmacological activation indicates that pharmacological compounds may have a tissue-specific modulation of this nuclear receptor's activity.
We explored the potential for the anti-hypertensive angiotensin II type 1-receptor (ATR1) antagonists to improve insulin sensitivity through modulation of the nuclear receptor PPARγ, in vitro and in vivo compared to the potent insulin sensitizer, rosiglitazone.
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
