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Endophilin B1, which is required for the modulation of normal mitochondrial outer membrane morphological dynamics, promoted Bax activation.
In normal cells, ROS are at low levels, which is pivotal for the modulation of normal cell proliferation.
These central mechanisms may involve spinal or supraspinal modulation of normal peripheral input, or efferent mechanisms that alter pain sensitivity at the periphery.
The importance of miRNAs in the modulation of normal and pathological immune function has been shown in multiple studies in which deregulation of miRNAs was demonstrated to accompany diseases associated with excessive or uncontrolled inflammation.
A recent study, with a similar approach to ours, showed that modulation of normal serotonin (5-HT) function by acute tryptophan depletion altered the connectivity of amygdala and ventrolateral frontal cortex during processing of emotional faces (48).
Mutations or alterations in any of these pathways could lead to neoplastic changes in non-cancerous cells or modulation of normal MHC I expression and immune surveillance by the host's immune system.
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Modulation of the normal periodontal defences could provide a favourable environment for colonization of H. pylori.
These results indicated that although CASP2 plays a role in the modulation of autophagy under normal conditions, autophagy does not regulate the levels of CASP2 in the absence of external stressors.
To evaluate whether the effect of CLA on Bcl-2 expression was due to modulation of ERα, ERα normal human breast tissue and cells were treated with CLA, E2 or CLA+E2.
Endogenous protein C, a vitamin K dependent glycoprotein that is synthesized by the liver, plays an important role in the maintenance of haemostasis and modulation of inflammation under normal conditions [ 4, 5].
Thus, loss of nNOS from dystrophic muscle shifts the myogenic/fibrotic balance toward fibrosis by loss of normal NO modulation of leukocytes and satellite cells.
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