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In human studies, NFR responsiveness has been used as a direct measure of nociception as well as an indirect measure of supraspinal modulation of nociceptive transmission.
The nociceptive flexion reflex can be used as a tool to investigate modulation of nociceptive transmission at spinal level.
Several lines of evidence have shown that unilateral hindpaw inflammation produces activation of the locus coeruleus (LC) and the nucleus subcoeruleus (SC), resulting in descending modulation of nociceptive processing in the dorsal horn.
The present study was designed to examine modulation of nociceptive processing in the caudal part of the trigeminal sensory nuclear complex, the trigeminal subnucleus caudalis which is generally considered to be involved in the relay of oral-facial nociceptive information.
Figure 2 Cerebral structures involved in the descending modulation of nociceptive information.
Experimental data suggest that the posterior hypothalamus is involved in the modulation of nociceptive processing in humans [29].
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The nociceptive flexion reflex paradigm is widely used to investigate modulation of nociception and represents a reliable objective measure of the functional activation of the nociceptive network.
Central facilitation and modulation of incoming nociceptive signals play an important role in the perception of pain.
Dynamic QST is one such test, and can probe both the ascending facilitation and descending modulation of incoming nociceptive signals via TS and CPM, respectively.
Our results suggest that sensory neuron-specific receptor may play an important role in modulation of spinal nociceptive transmission.
Legrain, V., Guerit, J. M., Bruyer, R. & Plaghki, L. Attentional modulation of the nociceptive processing into the human brain: selective spatial attention, probability of stimulus occurrence, and target detection effects on laser evoked potentials.
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