Sentence examples for modulation of microglial from inspiring English sources
Modulation of microglial activation, prevention of blood brain-barrier alterations, and use of antioxidants represent relevant therapeutic targets that may impact significantly on neurologic outcomes.
Modulation of microglial activation, prevention of BBB alterations, and use of antioxidants represent relevant therapeutic targets that may impact significantly on neurologic outcomes.
Collectively, this study shows that CA3 and CA1 hippocampal regions are highly responsive to GDNF-induced Ret receptor activation and neuroprotection, and suggest that, upon excitotoxicity, such neuroprotective action involves a GDNF modulation of microglial cell activity.
Collectively, this study shows that CA3 and CA1 hippocampal regions are highly responsive to GDNF-induced Ret activation and neuroprotection, and suggest that, upon excitotoxicity, such neuroprotection involves a GDNF modulation of microglial cell activity.
PPAR- α participates also in the PEA modulation of microglial cells [ 58].
The modulation of microglial functional states may be a useful tool to intervene in the progression of PD.
Although the general mechanism that generate IL-10 production within the CNS during neuroinflammation is still not well enough understood, our results support a role for α-Syn in the modulation of the microglial phenotype as suggested by Austin and collaborators [64].
Melatonin acts through its specific receptors by promoting oligodendroglial maturation and myelination repair together with modulation of astrogliosis and microglial activation in vivo and in vitro.
Finally, a robust and important decrease of OX-42 and ED-1 staining was observed in 3-AB treated animals in the early phase of ischemia, confirming that PARP-1 inhibition is an efficient approach for the modulation of local resident microglial activation and proliferation.
Taken altogether, the results of the present study suggest a possible interplay of microglial modulation and anti-oxidant effect in neuroprotective potential of hesperidin against QA induced HD like symptoms in rats.
Furthermore, MSCs modulate the inflammatory response of microglial cells, resident immunocompetent cells in the brain[111].
