Sentence examples for modulation of microglia from inspiring English sources

Here we describe a novel functional role for PS2 in the modulation of microglia behavior.

However, modulation of microglia activation towards an alternatively activated phenotype, favoring neuroprotection, can modify the outcome of some experimental models of neurological diseases [ 17].

Furthermore, since the change in microglia infiltration after Ex-4 treatment did not correlate either with the size of the ischaemic lesion or the stroke-induced stem cell proliferation and neurogenesis, it is unclear whether the modulation of microglia infiltration by Ex-4 has any significant impact on the ischaemic damage and stroke-induced neurogenesis.

Sildenafil reduced GFAP (25 and 50 mg/kg) and Iba-1 expression (25 mg/kg) in comparison to the cuprizone group, indicating the modulation of astrocytes and microglia, respectively.

The levels of enzymatic reconstitution/correction correlated well with the reduction of tissue storage, decrease of activated astroglia and microglia, modulation of inflammation, and improved survival [ 171].

The combined actions of astrocytes and Müller cells provide a supportive environment for the modulation of synaptic activity through the activation of microglia and the maintenance of ionic and neurotransmitter levels [ 23].

It is currently thought that the clinical benefits achieved by minocycline are the result of caspase-activated apoptosis, and its modulation of peripheral immunocompetent cells and microglia with regard to their release of cytokines, suppression of free radical production, and inhibition of MMPs [13].

We found a concentration-dependent modulation of p44 MAPK phosphorylation in microglia cultures.

These studies provide a novel mechanistic insight into helminth-mediated immune suppression in microglia via modulation of epigenetic processes.

To our knowledge, we show for the first time that ADAM17 inhibition leads to a concentration-dependent modulation of p44 MAPK phosphorylation in microglia and oligodendrocyte cultures.

We find that modulation of oxygen tension leads to loss of neurons, activation of microglia, accumulation of ROS in ependymoglia cells concomitant with their cell cycle reentry, and increased neurogenesis in the forebrain.