Sentence examples for modulation of ligand from inspiring English sources

These results support the use of IL-7tv as a novel agent for immune reconstitution and indicate that modulation of ligand binding to the IL-7R is a powerful means by which to harness the growth potential of the cytokine.

Possibilities include not only differences in the intrinsic affinity of Notch1 for various ligands, but also variation in ligand expression level, differential modulation of ligand affinity by glycosyltransferase modification of Notch1, variable ligand-mediated cis-inhibition in Notch-expressing cells, etc.

The simplest model describing allosteric modulation of ligand affinity at constitutive heterodimers is the ternary complex model.

In some cases, rather than a direct steric effect, mutual modulation of ligand binding at spatially separated sites may be achieved through a change in protein dynamics.

Equilibrium and kinetic experiments definitively establish that both O2 and CO bind cooperatively with no modulation of ligand affinity by non-heme ligands.

Both the AMPAR transmembrane region and the ligand binding domain (LBD) have been implicated in TARP interactions responsible for the modulation of ligand efficacy, pharmacology, gating, and pore properties (Jackson and Nicoll, 2011).

Domains I and II have a major role in the allosteric modulation of ligand-binding and reactivity properties of HSA, the FA1, FA2, FA6 and FA7 sites being functionally linked.

HCMV has evolved a variety of different mechanisms to evade NK cell activation that are based either on the expression of molecules that engage inhibitory NK receptors or on the down-modulation of ligands that engage activating NK receptors.

In addition to their direct killing capacity, AMPs can participate in other immune functions such as chemotaxis, wound repair, inhibition of apoptosis and modulation of TLR ligand signaling [1], [2].

The results obtained showing distinct structural characteristics of PCa FN compared to BPH FN could be important for modulation of its ligand and recognition properties expressed as gain or loss of functions or as specific markers of its origin.

In order to discover immunomodulating proteins, we added InterPro functional domain annotations to data from experiments PM1 and PM2 (Hunter et al., 2012) and reasoned that modulation of a ligand during HCMV infection may indicate biological importance.