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Modulation of levels of its message is certainly one place for regulation.
Our results suggest that it has a novel cytoplasmic role; modulation of levels of tubulin acetylation.
IUGR affects the IGF-1 histone 3 code along the length of the gene (1), appears to involve modulation of levels rather than simple on/off effects, and shows a degree of sex variability.
Deregulation of these mechanisms, e.g. by therapeutic modulation of levels of miRNAs that are important for the hypoxic response, may inhibit the adaptive potential of the cells, and reduce their resistance against radiation and systemic agents.
In such cases, the simulation can be directly extrapolated and this was shown, albeit qualitatively, when the predicted modulation of levels of branched chain amino acids in flazasulfuron-exposed E. coli could be verified experimentally and their actual levels confirmed in the M. tuberculosis surrogate, M. bovis BCG.
Furthermore, PAI-1 is a circulating adipokine, which is elevated in obesity, and high-fat diet-induced obese mice deficient in PAI-1 have reduced adipose tissue mass and increased insulin sensitivity, supporting a potential role for modulation of levels of PAI-1 activity in the treatment of obesity and its comorbidities.
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A modulation of level of transcripts is revealed with 2313 probes at least at one of the three stages of development.
The LPS priming mediated quantitative modulation of mRNA levels eventually affects all different regulatory levels controlling mRNA abundance.
We also examined whether PARP-1 activation contributed to the modulation of ATP levels and β-Lap could restore ATP levels altered by cisplatin treatment.
This increase in SIRT1 activity, rather than being the consequence of a modulation of NAD+ levels, was attributed to a higher expression level of SIRT1 [ 4].
This information suggests that changes in GA levels can couple the downstream regulation of growth and stress tolerance through modulation of ROS levels.
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