Sentence examples for modulation of kinase from inspiring English sources
Overall, we suggest that phosphotyrosyl ligand binding causes conformational changes in the SH3-SH2 and βB- βC linkers, part of the βD, and βD-βE linker region, thereby allowing for modulation of kinase activity.
Since over-expression experiments do not allow the modulation of kinase activity both in terms of timing and signal strength and, moreover, since the levels of transgene expression in selected clones were lower than in the heterozygous cells, the combination of these drawbacks might explain the incomplete rescue (Fig. 2A).
Phosphorylation of this residue is implicated in the modulation of kinase activity in human and in Arabidopsis[ 20, 35- 37].
Modulation of kinase activity can be accomplished by strategies other than inhibition of phosphorylation activity through the blocking of ATP binding.
For these reasons, pharmacological modulation of kinase functions is an attractive therapeutic option, also because protein kinases can be targeted by several small molecules and drugs.
These results open a way to explore the modulation of kinase pathway in an attempt to reduce the inflammatory process in this orphan disease.
Modulation of kinases involved in MAPK (Mitogen-Activated Protein Kinase) pathways could result in up-regulation of hypoxia signaling [ 44].
To recap, our current working model is that sorafenib is, in fact, most likely to inhibit system xc- activity through modulation of a kinase or kinase-like target.
Bryostatins are a family of macrolide lactone compounds with potent neurobiochemical, anticancer, and immuno-modulating properties both in vitro and in vivo, which operate putatively through modulation of protein kinase C (PKC).
In addition, modulation of protein kinase A (PKA) activity by chemical means causes a partial accumulation of Smo on a proximal segment of the primary cilium.
Likewise, genetic disruption of Fyn has recently been associated with peripheral tissue insulin sensitivity through modulation of AMP kinase activity [37].
