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HsPARP-1 is well investigated because pharmacological modulation of its activity modulates DNA-binding of antitumor drugs [1].
Perhaps the most important finding is that ParA does not form filaments but that it participates in chromosome segregation through a modulation of its ATPase activity stimulated by highly concentrated ParB at ParS sequences.
Therefore, modulation of its activity by the activity of the adjacent gene may make it difficult to interpret and predict gene expression output.
Suppression of vibration in predefined regions of the string is performed by continuous spatial modulation of its cross-section.
The adjustment of process parameters has allowed obtaining a pulsed laminar plasma and a modulation of its properties.
Caspase-9 can indeed be phosphorylated by the ERK MAPK pathway, with the resulting modulation of its function and consequently, of caspase-3 activation26.
Here an electron bunch first interacts with the accelerating field excited by a few-cycle laser pulse leading to modulation of its kinetic energy Ek.
Yu, J. et al. Ubiquitin ligase Cbl-b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability.
This important knowledge has paved the way for a novel structure-based molecular design for modulation of its catalytic activities.
This effect was supported by bacteria beneficial effect on photochemical apparatus and the modulation of its oxidative stress machinery.
Mechanistically, ellagic acid was found to prevent PI3K/Akt activation that in turn, results in modulation of its downstream Bcl-2 family proteins.
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