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Conclusion: Glutamine has a specific inhibitory effect on pro-inflammatory cytokine production in the gut and may contribution to the modulation of intestinal inflammation.
Recent observations made by our group have suggested the implication of the chloride channel CFTR in the modulation of intestinal lipid handling and transport [23].
Taken together, these findings debunk the myth that germ-free NOD female mice have increased diabetes incidence and support the notion that modulation of intestinal microbiota can have beneficial effects on the development of autoimmune diabetes.
These findings challenge the view that germ-free NOD mice have increased diabetes incidence and demonstrate that modulation of intestinal microbiota can prevent the development of type-1 diabetes.
These and related findings on the vagal modulation of intestinal inflammation are ably reviewed elsewhere [ 35].
Understanding the mechanisms behind these effects will facilitate modulation of intestinal health.
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Selective modulation of the intestinal microbiota with prebiotics reduces intestinal permeability and endotoxin concentrations, inflammation, and metabolic dysfunction in rodents.
Probiotic microorganisms exert their action through a temporary modulation of the intestinal bowel flora [ 9, 10] and by that might influence the intestinal immune system [ 11, 12].
However, this aspect might be interesting, since a modulation of the intestinal microbiota of the mother sows might also affect the bacterial community in the intestinal tract of their piglets.
These health-promoting effects may include the modulation of the intestinal microflora, prevention of rotavirus-induced or antibiotic-associated diarrhea, beneficial effects on gastrointestinal tract inflammation, modulate the mucosal immune responses (Roberfroid et al. 2010; Gourbeyre et al. 2011).
Three main approaches have been proposed as new therapeutic modalities for celiac disease: gluten detoxification, modulation of the intestinal permeability, and modulation of the immune response.
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