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Thus, the determination of individual gene expression patterns may facilitate the selection of the best medication or, more ambitiously, may allow directed modulation of (individually) selected pathways/complexes instead of broad suppression of inflammation by anti-inflammatory/anti-rheumatic drugs [ 84].
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Modulation of these parameters, individually or in combination, can dictate the specific type of protrusions migrating cells form.
The authors show that over-expression of p53 together with inhibition of NF- κB or STAT3 induced greater increase in the BAX/BCL-XL ratio than modulation of these transcription factors individually.
A result of such a simulation could be the expected accuracy and precision of this mechanism (GnRH modulation) for achieving a target E2 range, i.e., to quantify the potential challenge of individually targeting E2 in a diverse patient population.
In the case of individually rare mutations, ' n-of-1' level in vivo evidence of efficacy generated by crossover studies may be important in assessing and developing future CFTR modulation strategies and facilitating access to new drugs for patients [ 83].
This is in fact superposition modulation of multiple transmitters on a single subcarrier which is repeated individually for multiple subcarriers.
In case of explicit redundancy within the IL-10 cytokine family, modulation of their expression could prove more efficacious than targeting the cytokines individually.
Based on our data we can now suggest a model (Fig. 7) in which EPEC infection triggers signal transduction pathways that while individually lead to either filopodia or pedestal formation, when crossed over fine-tune modulation of actin dynamic for the benefit of the adherent bacteria.
Berger et al. [ 123] have suggested a model in which EPEC infection triggers signal transduction pathways that while individually lead to either filopodia or pedestal formation, when crossed over fine-tune modulation of actin dynamic for the benefit of the adherent bacteria.
Figure 2 shows a representative overlay of the visible spectra for all Fe FbpABp X assemblies prepared individually as described in Experimental Methods, indicating the anion promiscuity of FbpABp in sequestering Fe3+ and modulation of the position of the charge transfer (CT) bands by various anions (Table 1).
Willful modulation of brain activity in disorders of consciousness.
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