Sentence examples for modulation of important from inspiring English sources

SIRT1 acts as a nutrient sensor involved in the regulation of various gene expressions as well as modulation of important signal transductions either directly or indirectly through its unique epigenetic effects, which ultimately influence the regulation of longevity [14].

This function ultimately results in the modulation of important downstream signaling pathways and biological processes.

This evidence supports the effective participation of fibroblasts in the homeostasis of the marginal periodontium through secretion modulation of important inflammatory mediators.

For example, KCTD8, -12, -12b, and-16 form functional oligomers with the GABAB receptor, resulting in the modulation of important signaling pathways [ 21- 247]47].

The modulation of important parameters of gut physiology such as motility, absorption, differentiation and apoptosis depends on propionate, folate (vitamin B9) and nitric oxide (NO) production [ 1, 18].

Modulation of important factors including MCP-1, MIF, SCGF-β and/or SDF-1 is likely an important avenue for further investigation and ultimately therapeutic intervention.

Using Gene Ontology designations and the review of recent published literature, we observed that in addition to the expected genes modulated by UV irradiation, solar simulated irradiation induces the modulation of an important group of genes involved in immune response (Fig. 4).

However, after the completion of our analysis, the results of a high-throughput screen of more than 3,000 compounds against IDH1 have been deposited into the PubChem database64, heralding the beginnings of efforts towards the chemical modulation of this important target.

Modulation of this important innate sensing system could represent a novel means by which to prevent/attenuate development of CAC.

RASSF7 and RGL3 are significant signaling intermediates of the RAS pathway and their alterations indicate towards modulation of this important cellular signaling cascade by TNFα in HepG2 cells.

Our finding that Nodal signaling is maternally regulated by translational repression could allow modulation of these important therapeutic cells by this new mechanism.