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Kluwe J, Pradere JP, Gwak GY, et al. Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition.
A protection against Fe-NTA induced hepatic tumor promotion was also apparent as inhibition in the modulation of hepatic tumor markers viz., ornithine decarboxylase activity and DNA synthesis.
The present experiment was designed to evaluate the potential effect of α-mangostin mediated pharmacological modulation of hepatic carbohydrate metabolism in streptozotocin (STZ) induced diabetic rats.
These outcomes indicate that liver regeneration after partial hepatectomy involves modulation of hepatic energy economy in response to changing work demands.
They participate in many essential physiological processes, such as sympathetic neurotransmission, modulation of hepatic metabolism, control of vascular tone, cardiac contraction, and the regulation of smooth muscle activity in the genitourinary system.
Modulation of hepatic sterol and steroid metabolism is a plausible mode of action for changes in serum testosterone and adverse reproductive outcomes observed in rat studies, and may be relevant to human risk assessment.
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For example, although lipopolysaccharide-modulation of hepatic STAT3α in the absence of STAT3β was reported to be unperturbed, levels of STAT3α phospho-Tyr were lower at the 1.5 h and 6 h timepoints of treatment in the absence of STAT3β [ 15].
The mechanism by which GLP-1 regulates the hepatic glucose output appears to be related to the modulation of the hepatic insulin receptor GLUT2 complex endocytosis (7).
These results implied that CIP-A5 could selectively ameliorate the process of liver cirrhosis through modulation of activated hepatic stellate cell activity, which offers hope for prevention and treatment of this devastating end-stage liver disease.
Therefore, the modulation of the hepatic proteome related to metabolic pathways under low body temperature occurs at a haematopoietic site.
The present results have provided evidence for modulation of the hepatic kynurenine pathway by disulfiram, possibly via its carbon disulphide metabolite.
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