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The transcription of the genetic code from DNA to RNA, and the translation of that code from RNA into protein, exerts the greatest influence on the modulation of genetic information.
Growth and development is the net result of environmental modulation of genetic inheritance.
However, this is the first ever report demonstrating the intricate modulation of genetic network affected by NPs.
Our work demonstrates engineering of fully functional HSCs via modulation of genetic programs that govern self-renewal and lineage priming.
Thus, twin studies show that parenting influences children's prosocial behaviours and acts as a "modulation" of genetic influences.
Collectively, these trends demonstrate the contribution of targeted mRNA degradation to the transcriptional bottleneck and the modulation of genetic programs subsequently deployed.
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The observed deficits in learning performance and the lack of significant age modulation of the genetic association suggest a more general genetic effect.
It can cause many adverse effect (ageing) and pathological conditions (inflammation, cancer) via the modulation of biochemical, genetic and signal transduction pathways [1] [3].
11 It would be interesting to investigate this further in Asian populations as distribution of HLA subtypes varies across races and it has been suggested that this could lead to differential modulation of the genetic effects of PADI4.
In this vista, several natural products show a pivotal role in the activation of PPARs through the modulation of other genetic pathways and finally exhibit role in cancer prevention.
Furthermore, the modulation of the genetic effects by in utero characteristics, postnatal diet, activity, and postnatal rate of weight gain in relation to the growing offspring's adiposity has not been investigated.
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