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However, little is known about specific medication effects on the modulation of frontal activation during WM performance.
Alternatively, competition for frontal "workspace" might be stronger than in parietal cortex [13], correlating to stronger modulation of frontal activity as compared to parietal activation.
However, some studies do not find evidence for COMT modulation of frontal dopamine function.
Consequently, modulation of frontal theta, as observed here, may be an indication of hippocampal activity as a direct consequence of this phase relationship [Jensen and Lisman, 2005].
We speculate that dopamine modulation of frontal cortex function may explain the current results, given that dopamine plays a modulatory role in cognition through its extensive diffuse projections from midbrain dopamine nuclei to the basal ganglia and frontal cortical areas [ 29 31].
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We postulate that RATN theta oscillations are involved in two separate processes: modulation of frontal-RATN theta oscillations through long-range synchrony and modulation of RATN gamma oscillations through CFC.
If the contribution of the fornix to scene learning is via interaction with or modulation of frontal-temporal interaction − that is, if they form a unitary system − then Fx should have no further effect when added to frontal-temporal disconnection.
This study is the first to demonstrate that modulations of frontal theta-band oscillations, recorded during infants' object exploration, predict infants' subsequent recognition of these objects.
Transcranial Direct Current Stimulation (tDCS) is considered as a putative therapeutical approach in Major Depressive Disorder (MDD) allowing for a non-invasive modulation of dysregulated frontal activity (Kalu et al., 2012).
Thirdly, modulation of activity in frontal or frontoparietal "global workspace" should modulate activity in co-activated local processors, reflected by modulation of activity in visual or auditory cortex.
Moreover, based on the "global neuronal workspace" model, modulation of activity in frontal or frontoparietal workspace neurons should cause modulation of activity in co-activated local processors, e.g., visual or auditory cortex.
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