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As HBx protein is crucially associated with development of HCC and cellular miRNA expressions are shown to be perturbed by viral X protein, we aimed to obtain an insight into the possible role of HBx protein of HBV in the modulation of expressions of two oncomiRNA - miR-21 and miR-222 and one tumor suppressor miRNA - miR-145 in malignant hepatocytes.
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To investigate the modulation of expression of proteinase-activated receptor-2 (PAR-2) in articular chondrocytes by inflammatory cytokines.
One of the most important research subjects of metabolic engineering is the pursuit of balanced metabolic pathways, which requires the modulation of expression of many genes.
Rapidly replicating picornaviruses rely on posttranslational activation and/or specific recruitment of cellular proteins rather than on modulation of expression of cellular genes to create favorable membrane microenvironment.
Protein expression profiles were analyzed by difference gel electrophoresis to identify proteins that showed modulation of expression in response to these different environments.
LY294002 has also been reported to exert inhibitory effects on multidrug resistance-associated protein 1 (MRP1) function via dual mechanisms, competitive block of substrate transport and modulation of expression.
Thus, LY294002 can also exert inhibitory effects on MRP1 function via dual mechanisms, i.e., competitive block of substrate transport and modulation of expression.
In particular, modulation of expression and protein levels by Fe has been extensively studied [66].
Widespread modulation of expression is consistent with extensive developmental and physiological regulation of insulin-like gene expression.
No modulation of expression of DNA repair-related genes was detected between pre- and post-senescence MSC.
Modulation of expression of specific transcription factor genes has already proved successful in improving drought stress [41].
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