Sentence examples for modulation of effector from inspiring English sources

However, there is a wealth of functional diversity that is present in other isotypes and IgG subclasses that can be exploited to improve clinical safety and performance by increasing stability, reduction of adverse events, modulation of effector functions, and by the engagement of two antigens by a single antibody.

Clearly, direct hBD-3 modulation of effector functions of TAMs in vivo needs to be further elucidated.

Coupled with previous studies that have shown a modulation of effector responses to other pathogens [15], [16], [17] and to parenteral and oral vaccinations [20], [21], [22], the data from this study suggests that there are even more broad-reaching consequences of persistent filarial infection that provides additional impetus to treat filarial infections as early in life as possible.

Modulation of effector caspase activity may represent a novel approach to hasten the resolution of an inflammatory response.

Tumors commonly escape from elimination by the immune system by using multiple strategies, notably the active suppression and the modulation of effector immune cells.

These results suggest that an effective modulation of effector immune response to leishmanial antigens is difficult to be achieved by ML patients.

Because rapamycin modulated fat content of marmosets in the early periods of treatment, we assessed the potential modulation of effectors of lipolysis/lipogenesis in adipose.

TGF-β, however, remains a credible candidate for the functional Treg product in this system, with respect to both the induction and survival of Treg 63, and the down-modulation of effector T cell populations 64.

For example, Paracoccidioides brasiliensis attracts regulatory T cells (Tregs) to sites of infection, leading to down-modulation of effector immune responses and the long-term presence of the fungus in granulomas (Moreira et al. 2008).

In conclusion, given the highly complex mechanisms of differentiation, cytokine coexpression, and pathogenic or protective effector functions of Th17 cells, the specific modulation of Th17 effector functions is a major therapeutic challenge.

Antibodies contain a conserved glycosylation site that has emerged as a target for the modulation of antibody effector functions.