Sentence examples for modulation of downstream from inspiring English sources
DNA methylation might also affect AKI and kidney repair via modulation of downstream genes, but the nature of this regulation remains largely unknown.
Compound 5b stimulated p53 activation, caused modulation of downstream effectors p21, pRb, and cyclin D1 which regulate cell cycle.
Interestingly, the 'natural' bias of the CaSR is altered in disease states, and small molecule drugs engender biased allosteric modulation of downstream signaling pathways.
The data highlight the importance of temperature for the modulation of downstream movement, as well as the potential deleterious impact of the anthropogenic increase in river temperature below the spawning and juvenile habitat in the Allier tributary on the success of downstream migration.
In this review, we use the Grainyhead-like (Grhl) family as a case study to illustrate the importance of isoforms when investigating transcription factor family function during development and disease, and highlight the potential for differential modulation of downstream target genes.
Ca2+ signal transduction is involved in the detection of energy or oxygen deficits and the modulation of downstream mechanisms to promote anaerobic germination in rice (Lee et al. 2009).
A 10 Gbit/s differential quadrature phase shift keying (DQPSK) data signal is used at optical line terminal (OLT) for downstream, whereas a 2.5 Gbit/s inverse return-to-zero (IRZ) data signal with high extinction ratio is used for upstream signal by intensity re-modulation of downstream signal, no additional laser is used at optical network unit (ONU).
Mechanistically, ellagic acid was found to prevent PI3K/Akt activation that in turn, results in modulation of its downstream Bcl-2 family proteins.
These compounds also had unique profiles with regard to allosteric modulation of multiple downstream signaling (PathHunter β-arrestin signaling, PathHunter internalization signaling, microscopy-based internalization assay).
Many viruses have evolved strategies to neutralize TNF by direct binding and inhibition of the ligand or its receptor or modulation of various downstream signaling events [14].
The ECS comprises one of the most important weight regulatory systems in humans, since endocannabinoids have numerous effects on energy homeostasis by activating cannabinoid receptors throughout the nervous system and in the periphery [8] together with modulation of other downstream energy regulating molecules.
