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To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation.
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that utilizes weak direct currents to induce polarity-dependent modulation of corticospinal excitability.
Patuzzo and collaborators [17] found no evidence for differential modulation of corticospinal excitability during observation of self- and non-self finger movement.
We posit that the fronto-parietal network involved in multisensory integration may be the origin of the modulation of corticospinal excitability found in the present study.
The time-dependent modulation of corticospinal excitability due to near and far stimuli found in the present study captures this relationship between space and time in PPS representation.
Thus, a differential effect on MEPs associated with NEAR sounds compared to FAR sounds would reflect a modulation of corticospinal excitability of the hand motor representation due to the PPS representation.
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Motor resonance is the modulation of M1 corticospinal excitability induced by observation of others' actions.
This pattern of corticospinal modulation highlights the relation between space and time in the PPS representation: an early facilitation for near stimuli may reflect immediate motor preparation, whereas, at later time intervals, motor preparation relates to distant stimuli potentially approaching the body.
Analogously, in the motor domain van Elswijk and colleagues [ 12] presented data suggesting gain modulation of motor evoked potentials being related to instantaneous phase of corticospinal beta oscillations (around 20 Hz).
In this way, a MEPi = 100% indicates no modulation, MEPi>100% indicates an enhancement and a MEPi<100% indicates a reduction of corticospinal excitability with respect to the baseline.
Each of these complex neurotechnologies plays a significant role for the design of corticospinal neuroprostheses.
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