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The weaker modulation of contact points exhibited by PD patients in the blocked condition could have been due to action tremor.
No significant modulation of contact points to object CM location was found within the PD group in the blocked vs. random conditions (Fig. 2A, 2nd column).
We found that the maximum modulation of contact points was ∼2.5 times greater on the vertical (y-axis) than on the anterior-posterior (z-axis) dimension (Fig. 1), i.e., 13.8 mm and 5.5 mm, respectively.
We previously showed that mammalian chromatin undergoes constraints that results in a modulation of contact frequencies along some regions of the chromatin [ 4].
Modulation of contact sites may also provide the mechanism through which ligands of peripheral membrane benzodiazepine receptor [also known as translocator protein of the outer membrane (TSPO) ] act to inhibit mPTP opening and induce cardioprotection (Schaller et al., 2010).
Altogether, these observations are in agreement with the existence of a long-range (~100 kb) modulation of contact frequencies in gene-rich-TADs, suggesting that the constraints governing statistical helix organization underlie higher-order chromatin dynamics of a very significant part of the genome.
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Our devices operate as unconventional Schottky barrier transistors, in which switching occurs primarily by modulation of the contact resistance rather than the SWNT conductance.
As expected, controls exhibited clear differences in the modulation of fingertip contact points to object CM in the blocked vs. random condition.
In the blocked condition, PD patients exhibited significantly weaker modulation of fingertip contact points to CM location and larger object roll than controls (p<0.05 and p<0.01, respectively).
This deficit, coupled with weak anticipatory modulation of fingertip contact points to object CM, suggest that PD patients were unable to take advantage of sensorimotor memories gained from previous manipulations to the same extent as their age-matched controls.
Communication impairments may include a delay or lack of development of spoken language while social impairments are likely to encompass the poor modulation of eye contact, deficits interpreting facial affect, and a lack or atypicality of gesture during social interactions.
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transmission of contact
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