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The models differ in terms of connections, contextual modulation of connectivity, and driving inputs that perturb the network due to experimental events.
Compared to the most complex Model 1, which included condition-dependent modulation of all endogenous connections, Model 4 did not comprise modulation of connectivity between PFC or M1 and subcortical regions (putamen, thalamus, cerebellum) as a function of the experimental conditions (Fig. 3).
Modulation of connectivity strength between subcortical and cortical regions has been suggested as one possible mechanism.
Differences in resting-state connectivity of the BLA with various cortical regions in PTSD may be biasing the normal modulation of connectivity between these amygdala complexes and cortical regions during task engagement.
Our results add a new network perspective to our understanding of the neural underpinnings of emotion regulation, and highlight that connectomic methods can play a valuable role in comprehensively investigating modulation of connectivity across task conditions.
Abnormal dopaminergic modulation of connectivity between the putamen and cortex is thought to underlie the emergence of levodopa-induced dyskinesias.
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Our results therefore describe modulations of connectivity within the language network between overt and silent naming, rather than the entire underlying network.
Conversely, incongruent face emotion is associated with the same connectivity modulation in both groups: increased modulation of bidirectional connectivity of the OFC to both FG and amygdala.
This dynamic modulation of effective connectivity occurs orthogonal to changes in effective connectivity engendered through increases or decreases in the average firing rate of the STN.
The condition-specific modulation of endogenous connectivity does not necessarily affect all possible connections (Friston et al., 2003; Stephan et al., 2010).
Aertsen, A. M. et al. Dynamics of neuronal firing correlation: modulation of 'effective connectivity.' J. Neurophysiol.
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