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The detailed mechanism of these functions is complex and mainly involves cell apoptosis by modulation of complex molecular targets [9 13].
Nevertheless, the relative contribution of neurons and glia to the modulation of complex behavior and physiology during immune challenge is not known.
Insights into the mechanisms of interaction of death-fold domains will be useful to design strategies for specific modulation of complex formation and might lead to novel therapeutic applications.
This article discusses the novel functionality enabled by the addition or removal of SLiM-containing exons by pretranslational modifications, such as alternative splicing and alternative promoter usage, and how these alterations enable the creation and modulation of complex regulatory and signalling pathways.
The rapid regulation of complexes I and III, as well as the specific modulation of complex IV activity we observed, confirmed the key role of PRC for the rapid adaptation of cellular energy demand.
We next explored whether changes induced by modulation of complex I activity positively affected axonal transport.
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Numerical results for the phase modulation of the complex degree of spatial coherence are presented.
The perceived spatial location and spectral modulation of the complex tones were manipulated in the following way.
Our results suggest that metabolic reprogramming induced by modulation of mitochondrial complex I activity represents promising therapeutic strategy for AD.
Therefore, potential mechanisms of action for the likely anticancer activity of N-BPs, including ZOL, may act through modulation of several complex biochemical pathways downstream of FPPS inhibition.
Overall, the modulation of these complex pathways constitutes an important avenue for therapeutic interventions aimed at limiting oxidative damage or attenuating its consequent effects [ 1].
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