Sentence examples for modulation of channel from inspiring English sources

The development of more sensitive Na+ channel modulators should inevitably provide improved selective subtype and current type modulation of channel function, which may prove useful in treating oxaliplatin-induced neurotoxicity, as well as a variety of inherited and acquired Na+ channelopathies.

Although gap junction channels are relatively nonselective in their permeability to ions and small molecules, cardiac myocytes actively adjust their level of coupling by multiple mechanisms including changes in connexin expression, regulation of connexin trafficking and turnover, and modulation of channel properties.

Trafficking of voltage-gated channels therefore provides another way neurons may dynamically regulate excitability in addition to modulation of channel kinetic properties.

However, modulation of channel expression in hippocampal neurons occurred within 75 min [19] and in our experiments A- fiber nociceptor sensitivity was not seen to change for 2 3 h after rapamycin administration (Fig. 5), implying that regulation of A- fiber excitability by rapamycin was a relatively slow process.

Together, the data suggest an intimate involvement of different phospholipids with different connexins that contributes to modulation of channel structure, form and/or function.

The pore-forming α1C subunit of the L-type Ca channel contains > 10 cysteine residues, and a modulation of channel activity by thiol oxidizing agents is reported [151].

However, substituting Mg2+-ATP with NaCl resulted in significant run-down, indicating Na+-dependent modulation of channels containing SmCavβ.

Importantly, this may alter autonomic modulation of channels' functioning dramatically affecting the excitation-contraction processes and underlying pathophysiology of atrial remodeling.

We identified a TRPA1 (transient receptor potential A1) variant with increased sensitivity and differential modulation of channels by a tyrosine kinase inhibitor in neuroblastoma cells.

To further confirm a functional modulation of HCN2 channel properties by KCR1 additional single-channel recordings were performed.

Although the different KCNE peptides have diametrically opposite effects on Q1 channel function, the molecular mechanisms involved in KCNE modulation of Q1 channel gating are just starting to be revealed [14] [16].