They have been proven to be as potent as soluble cytoactive factors in the modulation of cell behaviors.
The anticancer effect of retinoic acid is attributed to the regulation of gene expression that results in the modulation of cell differentiation, proliferation, and apoptosis22.
This gene has been involved in the modulation of cell growth and the cellular response to gamma radiation probably via the regulation of the Akt signaling pathway60.
Clem RJ, Cheng EH, Karp CL, Kirsch DG, Ueno K, Takahashi A, et al. Modulation of cell death by Bcl-XL through caspase interaction.
We are continuing to use this 3D matrix to define the roles of matrix composition in modulation of cell adhesion and signaling.
Here, we review the most recent progress on engineering natural protein protein interactions for modulation of cell signaling.
Many chemical agents affect the skeletal system indirectly via mediator action on cell differentiation or modulation of cell function.
KBU2046's precision type of effect on chaperone function differentiates it from classical HSP90 inhibitors, which broadly disrupt client protein function, and underlie KBU2046's lack of toxicity and selective modulation of cell motility.
We thereby went on to demonstrate that precision modulation of cell motility could be achieved by selectively changing the signature of client kinase proteins bound to the HSP90β/CDC37 heterocomplex.
Increased ROS production, ultimately leading to irreversible oxidative damage of macromolecules or to more selective and reversible redox modulation of cell signalling, is a causative hallmark of mitochondrial diseases.
Vinck, M., Womelsdorf, T., Buffalo, E. A., Desimone, R. & Fries, P. Attentional modulation of cell-class-specific gamma-band synchronization in awake monkey area V4.
