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These studies underscore the potential of antimiR-based therapies for modulating cardiac miRNAs and validate miR-208 as a therapeutic target for the modulation of cardiac function and remodeling during heart disease.
Acute optogenetic modulation of cardiac twitch dynamics explored through modeling.
Muller, J. et al. Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction.
Shin, C. H. et al. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.
The evolution of DCM was associated with a modulation of cardiac lamin A/C protein level.
Experimental evidence support a key role for beta (1 -adrenergic receptor (ADRB1 -adrenergiculation of careceptorss.
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These results provide kinetic insights into the functional modulation of cardiac-type KATP channels by an intracellular signaling mechanism triggered by PKG.
Another mechanism of cell therapy includes the ability of transplanted cells to promote endogenous repair, which may include modulation of cardiac-resident stem cells and epicardial progenitor cells by specifically regulating endogenous or stem cell-derived paracrine factors.
Thermal noxious stimuli induced activation of LPGi serotonergic cells probably plays a key role in serotonin-mediated modulations of cardiac baroreflex and transmission of nociceptive messages occurring under such intense noxious conditions.
These findings suggest that physiologically relevant estrogen replacement therapy has blood pressure-independent cardioprotective effects, which are possibly mediated through modulation of the cardiac renin-angiotensin system.
Thus, reduced cardiac sympathetic innervation in heart failure is associated with elevated levels of inflammatory cytokines, suggesting that it has a potential inflammatory effect via modulation of the cardiac production of these cytokines.
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