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Our results suggest that miR-16 is a common regulator of cell fate in the mechanisms of steroid hormone or growth factor modulation of breast cancer cell proliferation.
Another signaling pathway involved in the modulation of breast cancer cell proliferation is mediated by the receptor for sex hormone-binding globulin (SHBG-R).
To explore a potential role for IGF II in the growth modulation of breast epithelial cells by NAF and CAF, the level of expression of IGF II in CAF versus that in NAF was assessed.
These results suggest that miR-16 is regulated as part of the ligand-induced PR effects observed in breast cancer, but would not be involved in PR modulation of breast cancer growth in the absence of the ligand.
Complex IGFBP-3 modulation of breast cancer growth has prompted several studies to examine levels of IGFBP-3 in breast cancer tissues in relation to clinicopathological characteristics and patient outcome [ 23- 26].
We first examined the modulation of breast cancer cell survival in the presence of IGF-I, IGF-II, FGF-2 or EGF, and we confirmed that, except for EGF, these growth factors promoted MCF-7 and T47D cell survival in vitro under serum-free conditions.
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There was no change in cytomorphology index score, but there was a significant favourable modulation of mammographic breast density, breast tissue ER expression and serum insulin-like growth factor (IGF -1/IGF bIGF -1/IGFtein-3 ratio.
Compared with placebo, there was no change in cytomorphology index score, but there was a significant favorable modulation of mammographic breast density, breast tissue ER expression and serum IGF-1/IGFBP-3 ratio.
In our present study, we employed RNAi techniques to suppress the BST2 expression to investigate the effects of BST2 modulation on breast cancer cell proliferation, migration and invasion.
Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.
In order to explore generic features of the modulation of human breast cell growth by genistein, its effects on cell lines MCF-7, ZR-75.1, T47-D, MDA-MB 468, MDA-MB 231 and HBL 100 were compared.
More suggestions(15)
transmission of breast
alteration of breast
variation of breast
transfer of breast
modification of breast
modulation of virus host
modulation of scFv
modulation of receptor
modulation of brain
modulation of pain
modulation of inflammation
modulation of calcineurin
modulation of activity
modulation of pHi
modulation of cholesterol
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