Sentence examples for modulation of bone from inspiring English sources

The similar phenotypes obtained using two different methods of manipulation indicate that the effects on bone formation are specific, and strongly suggest that spp1 has an essential role in the modulation of bone formation in zebrafish.

We used MLO-A5 cells to develop a system for studying the mechanical modulation of bone matrix formation in 3D using a cyclic compressive loading stimulus.

The involvement of the sympathetic nervous system (SNS) in the modulation of bone adaptation to its load-bearing demand remains controversial.

The biomechanical feedback system involved (bone 'mechanostat') would not control bone mass to optimize bone strength; it would rather control bone material quality and architecture (through a modulation of bone modeling and remodeling) in order to optimize bone stiffness.

But beyond modulation of bone formation, vitamin D has an impact on the innate and adaptive immune response in the field of osteoimmunology and could therefore influence early implant healing [19, 44 49].

Collectively, these data reaffirm the dynamic nature of bone formation and resorption at the implant-bone interface, even in early healing stages, and suggest the possibility for implant surface technology modulation of bone remodeling.

In line with earlier studies, mutual correlation analysis strongly suggested that the characteristic elastic modulations of bone lamellae within single units are the result of the twisting fibrillar orientation, rather than compositional variations, modulations of the mineral particle maturity, or mass density deviations.

Because the modulation of endochondral bone formation, like long bones, is controlled by both local and systemic factors, further studies should focus on matrix synthesis, as well as local and systemic factors to understand the underlying mechanisms that cause the differences observed here.

However, whether this apparent chondroprotective effect is mediated through modulation of subchondral bone turnover [ 10], either in part by effecting the peri-articular bone as suggested by Lin et al. and Behets et al [ 10, 11] or as a direct effect of calcitonin articular cartilage, remains to be elucidated.

Results of an in vitro study suggest that these effects are mediated by direct inhibition of osteoclast activity and modulation of the bone microenvironment through alteration of the receptor activator of nuclear factor-κB ligand (RANKL; also known as TNFSF11):osteoprotegerin ratio in osteoblasts80.

Tissue mineral density increased slightly from 6 to 16 wks of age, and although the effects of this increase on tibial stiffness were not directly measured, its role in the modulation of whole bone stiffness was likely minor over the age range examined.