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These results demonstrate the importance of plexinD1 in directing migration of maturing thymocytes via modulation of biological responses to chemokine gradients.
This could imply a modulation of biological activity, as observed for cathepsins B and L in the presence of GNP [64] possibly leading to an impairment of the cell machinery, a recognition of immunoglobulins or unfolded protein leading to macrophage activation [55],[65] and inflammation [66].
MicroRNA-mediated modulation of biological systems has been found to be perturbed in multiple diseases [5], including cancer [6] [8].
Although QDs have been used for high-resolution imaging in biological systems, they have not yet been used for simultaneous modulation of biological function.
Curcumin shows the chemopreventive effect in various types of tumor via modulation of biological processes.
Ion channels are emerging as interesting targets for the modulation of biological function in both inflammatory and structural non-excitable cells 12, 13.
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Therefore, modulations of biological effects might be attributed mainly to differences in the concentrations of PCBs.
During dietary fat-induced development of obesity and insulin resistance, we found substantial changes in gene expression in the small intestine, indicating modulations of biological processes, especially related to lipid metabolism.
Synthetic biology encompasses the design of new biological parts and systems as well as the modulation of existing biological networks to generate novel functions.
Gene expression analysis documented a precise sequential regulation of known genes involved in angiogenesis, Schwann cells/axons interactions and myelination, together with a selective modulation of key biological pathways for nerve morphogenesis induced by porous matrices.
In this work, we developed a computational framework for proposing associations between the ADRs of clinically approved drugs and the modulation of underlying biological pathways.
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