OVs can induce autophagy and immunogenic cancer cell death which may be potentiated by co-administration with autophagy modulators as modulation of autophagy may enhance tumor immunogenecity [ 29].
Therapeutic modulation of autophagy: which disease comes first?
Cho, S. J. et al. SUMO1 promotes Abeta production via the modulation of autophagy.
Galluzzi, L., Bravo-San Pedro, J. M., Levine, B., Green, D. R. & Kroemer, G. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Wu, Y. T. et al. Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase.
Antioxidants NAC and resveratrol confer protective role in Mn toxicity mainly through maintaining mitochondrial dynamics and function, other than a modulation of autophagy flux.
In this study, we identified that serine-metabolizing enzyme PHGDH plays an important role in the maintenance of self-renewal and poorly differentiated state of the CSLCs through modulation of autophagy.
Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, et al. Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy.
The modulation of autophagy in the secretion of IFN in virally-infected cells is controversial.
These studies suggested that modulation of autophagy might lead to therapeutic interventions for diseases associated with inflammation.
HIV-1 plays a complex role in modulation of autophagy within cells infected by the virus.
