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Overall, lupeol and β-sitosterol are reported to have multi-target action with immense anticancer potential modulating key signalling pathways that are implicated in various types of cancer, modulation of antioxidant enzyme levels in disease states, and reducing free radical generation [ 52, 57].
Locato, V., Gadaleta, C., De Gara, L. & De Pinto, M. C. Production of reactive species and modulation of antioxidant network in response to heat shock: a critical balance for cell fate.
In this study, we hypothesized that the modulation of antioxidant enzymes and redox status through a cranberry extract (CBE enriched diet would differ between obese and nonobese mice.
Results seem to support redox-mediated extremely low-frequency electromagnetic fields effects on biological models as, although no major oxidative damage was detected, after exposure we observed a positive modulation of antioxidant enzymatic expression, as well as a significant increase in reduced glutathione level, indicating a shift of cellular environment towards a more reduced state.
Lipid peroxides are expressed as pmols of thiobarbituric acid reactive substances (TBARS) per dry weight of mycelia and represented as the mean ± SEM from three separate experiments Fig. 4 Modulation of antioxidant enzyme activities in A. flavus mycelium by fullerene C60 nanoparticles (nC60) during 168 h growth period in YES medium at 29 °C.
Another Nrf2 target gene, p62 is involved in modulation of antioxidant and inflammatory activities.
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The research presented here showed modulations of antioxidant parameters, the total antioxidant capacity and oxidative damage in the form of lipid peroxidation associated with the respiratory disease caused by a natural infection with M. gallisepticum of grey partridges.
Modulation of these antioxidant defenses clearly contributed to the antioxidant and hepatoprotective activity of BHE.
Oxidative stress is particularly prevalent in neurodegenerative injury and, as astrocytes are central to antioxidant defence in the CNS, modulation of astrocyte antioxidant abilities has been considered a potential therapeutic target in altering the clinical course of such disorders.
This finding is in line with our previous report that demonstrated a distinct capability of EPC to induce and modulate strong cyto-protective properties in differentiated endothelium through modulation of intracellular antioxidant defensive mechanisms and pro-survival signals [13].
In addition, the role of autophagy in AMD and prevention of oxidative stress through modulation of the antioxidant system will be explored.
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