Sentence examples for modulation of alternative from inspiring English sources
This indicates that some of the therapeutic benefits of HDAC inhibitors may be due to the modulation of alternative splicing.
Therefore, modulation of alternative splicing by differential gene methylation could lead to differentiation-related differences in the resulting proteins.
We have shown that exon-skipping ASOs can be used to phenocopy certain diseases by gene-targeted modulation of alternative splicing.
Therefore, A-to-I RNA editing has important implications in altering specific amino acids, miRNA targeting, and in the modulation of alternative splicing (Nishikura 2010).
To date, functions ascribed to raver-2, similarly to its homologous raver-1 (47), include the modulation of alternative splicing through the splicing repressor PTB (20).
Raver1 is a member of the heterogeneous nuclear ribonucleoprotein family (hnRNP) that shuttles between the nucleus and cytoplasm and is involved in modulation of alternative splicing mediated by PTB (Polypyrimidine Tract-Binding protein) (Gromak et al., 2003).
For example, modulations of alternative splicing occur for Arabidopsis SR protein homologues, atSR30 and atSR45a, in response to environmental stress [12].
Therefore the existence of an auto-regulatory loop involving p53-dependent modulation of SIRT1 alternative splicing may provide insight into the coordination of these complex processes.
Therefore, modulation of an alternative cellular pathway(s) remains an open candidate for mediating the effects of PHD3 loss in malignancies.
Whereas retrovirus-forced expression of WSB1 isoforms 1 and 2 promoted cell growth and sensitized the cells to gemcitabine- and doxorubicin-induced apoptosis, WSB1 isoform 3 expression reduced cell proliferation and enhanced resistance to apoptosis, showing that stress-induced modulation of WSB1 alternative splicing increases resistance to apoptosis of pancreatic cancer cells.
The present pharmacokinetic study investigates the potential for modulation of these alternative pathways of IF metabolism in vivo using the adult male Fischer 344 rat model.
