Sentence examples for modulation of aging from inspiring English sources

Landmark studies in yeast and C. elegans have identified a genetic basis for the modulation of aging phenotypes that extends to higher organisms [2], [9].

Rasgrf1 deficient mice are therefore another model to study the modulation of aging by the GH/IGF1 axis.

The increase in ROS and its promotion of physiological processes of aging emphasizes the importance of understanding the molecular mechanism of ROS-linked modulation of aging, longevity and resistance to oxidative stress [ 11].

A role for ATF4 in modulation of aging was suggested by evidence that lifespan extension in yeast, whether caused by 60S ribosome mutations, lower TOR function, or nutrient deprivation, depended on the yeast homologue, Gcn4 (Steffen et al., 2008).

Some researchers hope that development of new means of introduction of antioxidants into cells or construction of new antioxidants can make a breakthrough in antioxidant modulation of aging and longevity.

Our studies suggest that the ASK1-signalosome serves as an ROS-sensory system that regulates the activity of the ROS-responsive physiological signaling processes that link ROS levels to the modulation of aging characteristics.

The recent development of small molecules that interfere with specific histone modifiers and their use in clinical trials, should provide new opportunities for the therapeutic modulation of the aging phenotypes in the future.

Metabolomics, the quantitative profile of endogenous and exogenous small molecules present in biological systems, had successfully been applied to study the modulation of the aging processes following nutritional interventions, including caloric restriction in mouse [ 10], dogs [ 11], and non-human primates [ 12].

Our observations suggest that regulation of this pathway is susceptible to modulation by the combined effects of aging, nutrition and metabolic status, which would have important implications for the maintenance of colorectal tissue homeostasis.

This then prompts the question: to what extent could chemical modulation of protein aggregation alter the rate of aging?

Hallmarks of aging include impaired default network modulation and declining medial temporal lobe (MTL) function.