Thourson, SB; Payne, CK, Modulation of action potentials using PEDOT PSS conducting polymer microwires, Scientific Reports, vol 7 no. 1 (2017) [abs1038/s41598-017-11032-3] [abs].
In what follows, we present 2 experiments showing the modulation of action dynamics across learning.
We discuss possible alternative approaches to obtaining precise control of neuronal spiking with AIS-targeted optogenetic constructs and propose potential uses for our ChR2-YFP-NavII-III probe where subthreshold modulation of action potential initiation is desirable.
For example, Schutte and Spencer [10] have used a computational model based on dynamic field theory [9] to account for the modulation of action dynamics when moving across different spatial extents.
While this study provide a clear evidence for a specific modulation of action language on M1 activity, the use of a passive task and, therefore, the lack of an online measure of the participants' performance, make it difficult to establish what sort of processing they have been actually performing, when M1 was stimulated.
The axon initial segment (AIS) is responsible for both the modulation of action potentials and the maintenance of neuronal polarity.
However, the direct measurement of ICl.PKA from cardiac cells and of its modulation of action potentials under physiological recording conditions is confounded by a lack of potent and selective pharmacological CFTR inhibitors [2].
Statistical analysis of the strength of theta modulation of action potential discharges revealed significant differences between the three cell classes (modulation strength, from the highest to low: AACs: r = 0.44 ± 0.1; BCs: r = 0.25 ± 0.1; Bistrat cells: r = 0.17 ± 0.05; p < 0.01; Kruskal Wallis test; Figure 1C).
One potential clue was our observation that, as mentioned above, 2 out of the 5 AACs for whom theta, gamma, and epsilon-related firing could be analyzed showed significant modulation of action potential discharges during running-associated epsilon waves, indicating a certain amount of intra-class heterogeneity among AACs as well.
This 400 ms time window of analysis was based on previous studies that showed temporal modulations of action and intention decoding within the first 400 ms of information processing [40].
