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Transfusion-related immune modulation might explain why standard plasma transfusions seem to be associated with some adverse events, such as multiple organ dysfunction syndromes and an increased risk of contracting nosocomial infections.
In larval zebrafish, several commissural interneuron subtypes have been identified [ 25 27] that might serve as putative targets for descending vSPNs, and their modulation might explain the specific frequency changes that occur when a forward swim gets switched into a turn.
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This enhanced flexibility and its modulation by phosphorylation might explain some of the functional antagonism between the closely related homologs FKBP51 and FKBP52.
(It is perhaps worth mentioning that, although modulation of muscarinic receptors might explain changes in smooth muscle tone, it seems less clear that it could account for the relaxation of skeletal muscle, for which cyclobenzaprine is used).
This effect and the modulation of GABA-mediated transmission might explain CSD inhibition by gabapentin.
Differential sequestration of these factors by polymorphic regions of the Y chromosome might explain the modulation of both PEV and genome-wide gene expression.
However, little is known about the interactions between these factors and possible cross-regulatory signalling that might explain the modulation by switching, such as microRNAs (Jennewein et al., 2010).
Therefore, the modulation of BCL6 by miR-10a might explain, at least in part, why the downregulation of miR-10a during DLBCL carcinogenesis can promote cell growth and accelerate DLBCL formation.
Therefore, the modulation of FEAT by miR-16 might explain, at least in part, why the downregulation of miR-16 during carcinogenesis can accelerate cancer progression.
The differences in the affinity might explain the difference in their amenability to pharmacological modulation.
This might explain why we observed a larger effect on AMPK activation and Thr phosphorylation by modulation of Akt in intact cells than in cell-free assays (compare Figures 1 and 3 with Figures 4– 6).
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