The initial clues that modulation of sirtuin activity might affect AD pathology came from studies reporting that a sirtuin agonist, resveratrol, was able to attenuate cell death induced by Aβ and oxidized lipoproteins in cell culture models.
Glutathione and glutathione S-transferase are involved in the detoxification of alkylating agents and cisplatin, so the modulation of their activity might affect the resistance to these compounds [ 68].
Therefore, our data suggest that loss of the negative modulation of MCH-mediated signaling via Gi/o might affect vesicle dynamics in the presynaptic terminal.
In addition to regulation through the AMPK/mTOR axis, calcineurin might affect autophagy by transcriptional modulation.
For further investigating how motion adaptation might affect the environment-dependent response modulations we selected two scenes that showed prominent time-dependent response modulations (TDRMs).
Therefore, the endocannabinoid system might affect eating behaviour through the modulation of the reward circuit [ 148].
Together with the data showing an OPA1 knockdown-induced MyHC decline, we speculated that ROS might affect MyHC content through the modulation of OPA1.
While suggesting that the present priming effects reflect the modulation of holistic face processing, lower level vision factors that might affect performance should also be considered.
Recent work suggests that vascular endothelial growth factor (VEGF) has a central role and that VEGF inhibitors might affect cognitive functioning through action on neurogenesis, cerebral blood flow and modulation of long-term potentiation [92,93].
