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Thus, future studies of isoform-specific PLC modulation may lead to treatments for migraine and its comorbid conditions.
Such aberrant modulation may lead to carcinogenesis and drug resistance.
However, top-down modulation may lead to an additional perceptional bias, for example, towards positive stimuli, and may depend on context factors such as the listener's sex.
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It provides an effective modulation that may lead to non-monotonic behaviour.
Modulation of apoptosis may lead to aberrant hemopoiesis and neoplastic progression.
Competition between burst-induced and confinement-induced modulation may hence lead to a non-monotonic modulation.
Although the first neurological event leading to migraine pain is still not completely understood, it has been suggested that dysfunction of the brainstem involved in the modulation of craniovascular afferents may lead to activation of ascending and descending pathways with onset of a perimeningeal vasodilatation and neurogenic inflammation [18].
For faster rates of one call per 313 ms, responses are reduced to 27% and 21% of 5000 ms levels, rendering support for the idea that call rate-dependent modulation of neural responses may lead to an overall reduction in energetic expenditure on communication.
These data suggest that modulation of CNS activity may lead to impaired HRV.
Dopaminergic disruption selectively obliterates this intrinsic sensitivity to valenced outcomes, although overall behavioral performance is maintained, and this is suggestive that modulation by l-dopa may lead to aberrant attachment of salience to nonsalient outcomes.
Such modulation of immune function may lead to recurrent infection, and the most commonly reported long-term effect on the pulmonary system from persistent exposure to Cs or other radioisotopes is increased pulmonary infection (Yablokov 2009b).
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