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Such modulation may enhance or depress effects of these agents.
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OVs can induce autophagy and immunogenic cancer cell death which may be potentiated by co-administration with autophagy modulators as modulation of autophagy may enhance tumor immunogenecity [ 29].
Finally, we provide several lines of evidence that miR-30-mediated modulation of the ubiquitin pathway may enhance recombinant protein expression in CHO cells.
Modulation of the cytokine environment may enhance both protective and vaccine-induced responses.
We hypothesize that metformin may enhance the inhibitory modulation of thyroid hormones on central TSH secretion.
RARβ2 induces expression of several members of the C/T antigen family found on Xq28 as well as interferon signalling genes (Tables 2 and 3), suggesting that therapeutic modulation of RARβ2 in tumor cells may enhance endogenous immunity or potentially be additive to therapeutic immunomodulation.
Modulation of cell surface targets by viruses may enhance viral replication directly, in a cell-autonomous fashion, or indirectly, through effects on non-infected cells or the immune response.
IL-6 was shown to enhance TGF-β1 signaling via modulation of TGF-β1 receptor trafficking, an effect that may enhance renal fibrosis [ 48].
Germanium (Ge) is compatible with Si technology and thus may enhance the performance of Si-based solar cells by modulation of the bandgap to optimize the solar spectrum harvest.
However modulation of these molecules by a variety of mechanisms (e.g., gene therapy, antisense oligonucleotides, small interfering RNA) may enhance the efficacy of radiation therapy by modifying the activity of these key cell proliferation and survival pathways.
Our results suggest that selective modulation of the innate immune response with a PDE4i can favorably alter the kinetics of INH-mediated bacillary killing and may enhance the efficacy of TB drug therapy.
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