In conclusion, these studies reveal that stromal cells can modulate the inflammatory response mediated by EC and that this modulation may itself depend on the state of the stromal cells in question (e.g. their own exposure to a chronically-inflamed environment).
Similar to what has been proposed for FGFR signalling, positive versus negative modulation of EGFR activity may depend on the ligand which activates the receptors.
In contrast, CsA-cardioprotection was preserved in the aged murine heart subjected to acute IRI (Peart et al., 2014), suggesting that the modulation of CsA-cardioprotection may depend on the particular confounding factor.
These findings highlight the complexity of the brain's response to stress, and they imply that modulations on AMPAR phosphorylation may depend on the species, the stress procedure, and the brain region studied.
According to our previous findings, activation of the EBV lytic cycle triggered by TERT inhibition may depend on modulation of BATF, a negative regulator of BZLF1, the main inducer of the viral lytic cycle.
Demonstrating efficacy and target modulation in future midostaurin trials may depend on preselecting patients with constitutively activated (phosphorylated) midostaurin targets: PKC isotypes α, β and γ, FLT3, c-kit, KDR, and PDGF receptor α and β.
The expression of one set of CbfA-dependent genes requires at least the JmjC/ZF domain of the CbfA protein and thus may depend on chromatin modulation.
The success of heterologous boost vaccines may depend on the modulation of the existing mycobacteria-specific T-cell repertoire to possess more "favorable" functional characteristics, rather than inducing de novo T-cell responses.
These results suggest that modulation of neurabin on the synaptic plasticity may depend on brain regions, age of animals, slice preparations, genetic manipulations or acute versus chronic lack of neurabin.
