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The fact that this is an insulin sensitive pathway suggests that inflammatory modulation may alter insulin signaling in overweight men.
In fact, such modulation may alter the plasma membrane-bound TrkB receptor level, making it difficult to predict the long-term effects of cyclotraxin-B.
Non-specific modulation may alter many signalling pathways making difficult the prediction of the final cellular effect.
Understanding the paradoxical role that the immune system plays in cancer and increasing options for their modulation may alter the odds in favor of a more effective anti-tumor immune response.
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This miRNA-mediated differential modulation of DRD1 expression may alter the density of the DRD1 receptor in the brain.
TACE can shed proinflammatory (sol-TNF) and anti-inflammatory (TNFR-1 and TNFR-2) substrates (20); hence, modulation of TACE activity may alter cellular inflammatory balance.
Thus, although adrenergic stimulation may affect the relative importance of SR Ca2+ release in E-C coupling, temperature-induced modulation of β-adrenoceptors may alter the efficacy of adrenergic effects.
Importantly, this may alter autonomic modulation of channels' functioning dramatically affecting the excitation-contraction processes and underlying pathophysiology of atrial remodeling.
It is possible that modulation of O-GlcNAc levels may alter the development of neuronal morphology at later stages of development than examined in our study, when dendrites differentiate from the minor processes and synaptogenesis begins.
When engineering fungal laccases a single amino acid change in the coordinating sphere of T1 copper may alter the complex modulation of laccase redox potential [ 36].
Modulation of biotransformation pathways by OH-PCBs may alter xenobiotic metabolism leading to the production of toxic reactive molecules, altering pharmacokinetics and diminishing the clearance rate of individual chemicals from the organism.
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