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On the one hand, the observed tuned modulation in responsiveness to sucrose was found in older pre-foraging bees (bees of two weeks of age), which are those that often receive and process the nectar coming into the nest.
DOI: http://dx.doi.org/10.7554/eLife.03185.017 The apparent increased modulation in responsiveness to calls during touch could be due to a sampling artifact as only a fraction of calls (19.8%) occur during touch.
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A question of current interest is whether the variability in cortical responses results from noise and imprecision in neuronal integration, or else reflects functionally significant modulations in responsiveness".
Its modulation in immune reactivity is well known in mammals and the drug is regarded as a flexible means to manipulate host responsiveness to malignancies and infections in a variety of ways [ 11, 13, 19, 20].
Metastatic melanoma (MM) and stage IV renal cell carcinoma (RCC) are two diseases commonly used for testing experimental immunotherapies due to a well described history of responsiveness to immune modulation in these indications [ 17, 37].
These data highlight direct PKCalpha-c-Src-ERalpha interactions, which may be crucial in the modulation of estrogen responsiveness and the differentiation process in osteoblasts.
This result shows that arginase activity in the airways is also involved in the modulation of airway responsiveness by limiting cNOS-derived bronchodilating NO production.
A biphasic modulation of responsiveness of spleen lymphocytes to mitogens was observed in mice exposed to 2,450-MHz 2,450-MHz at poweradiationes of 5-15 mW/cm2 over vatious powerdensitiesg between ofe and 17 days.
DOI: http://dx.doi.org/10.7554/eLife.03185.016 10.7554/eLiFigure85 figuregure 5—figure supplement 1. Sampling bias does not account for modulation of responsiveness to calls during touch; calls both from own and stimulus animals lead to increased modulation in primary auditory cortex during touch.
This is particularly relevant given the recent finding that in prefrontal cortex, during slow oscillation, there is a fine balance between excitation and inhibition that "may allow for rapid transitions between relatively stable network states, permitting the modulation of neuronal responsiveness in a behaviourally relevant manner" [80].
In order to gain insight into how auxin signaling induces growth cessation and dormancy onset, it is imperative to identify the molecular regulators that mediate SD modulation of auxin responsiveness in perennial plants.
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