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Feeding of root extract of P. senega to mice (at the rate of 50 mg/kg and 100 mg/kg bw) chronically treated with the carcinogen (50 mg/kg bw dissolved in olive oil) showed positive modulation in expression of signal proteins.
Finally, a significant modulation in expression of genes related to cellular proliferation and differentiation was observed.
The 44 proteins showing modulation in expression levels were subjected to amino acid sequence analysis, as described in Methods.
The TF genes ACE2 and CLR-2 showed no significant modulation in expression (P <0.05) between the various carbon sources.
TFs were scored by the modulation in expression level of genes that the TFs bind in the upstream region according to ChIP-chip data [ 24].
For miRNAs with age-related modulation in expression, the contrast between the 20 down-regulated and 81 up-regulated miRNAs in adults is displayed in Fig. 3A.
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Induced resistance is based upon modulations in expression of defense related genes.
In cancer, an array of molecular abnormalities leading to the modulations in expression of key proteins important in the cellular signaling pathways and cell proliferation has been identified.
Modulations in expression of TJ-associated proteins, particularly claudin proteins, have been shown in a number of cancers.
Knowledge gained from the characterization of modulations in expression of genes as a result of exposure to different carcinogens could one day provide a fingerprint to enable design of precise treatment strategies for specific individuals exposed to different toxicants.
Such observations suggest that modulations in expression of the candidate genes examined may be transient following low-dose treatment or that other factors are responsible for the effects observed, for example, oxidative damage (Jiao et al. 2007; Rajapakse et al. 2005).
More suggestions(15)
alteration in expression
diversification in expression
modification in expression
modulation in pressure
modulation in pain
modulation in signal
modulation in term
modulation in cancer
modulation in gene
modulation in high-frequency
modulation in multi-frequency
modulation in sleep
modulation in event
modulation in melanomagenesis
modulation in response
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