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RNAi by synthetic siRNAs in cardiomyocytes displayed very low efficacy and stability even in vitro, and pharmacological approaches to PLB modulation have failed so far.
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On the other hand, activity measurements on zymograms have failed to detect glucan phosphorylase activity modulation at least in the first 48 days [ 38].
Nearly all have failed.
"They have failed miserably".
Your policies have failed.
You have failed.
Governments have failed.
Ethically, they have failed.
Others have failed.
They have failed.
Activists have failed.
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