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In Escherichia coli, dimerization is mediated by the hibernation promotion factor (HPF) and ribosome modulation factor.
Contrary to ribosome modulation factor, the C-terminal domain of HPFlong binds exactly at the dimer interface.
Yoshida, H. et al. The ribosome modulation factor (RMF) binding site on the 100S ribosome of Escherichia coli.
The compression ratio is found to be by far the most dominant modulation factor.
The data showed a clear polarization signal, with a measured modulation factor of 0.42±0.01.
The measured modulation factor is well consistent with that from simulation, up to ~0.6 above 6 keV.
The mechanism in E. coli is mediated by the ribosome modulation factor (RMF 10, which binds to a site in the 30S and interferes with the Shine Dalgarno (SD) sequence.
Respectively, the modulation factor for protons, electrons and positrons are given for energies as low as 5 MeV for the mentioned period.
Therefore, it is necessary to carefully select the scattering geometry which can provide the highest modulation factor and thus highest sensitivity within the specified experimental constraints.
The sensitivity of such experiment is determined by the collecting area, scattering and detection efficiency, X-ray detector background, and the modulation factor.
(c) Population average of feature modulation factor for VPm neurons with and without LC stimulation in awake rats (1 without LC stimulation vs 1.11±0.04 during 5 Hz LC stimulation, n=19 features across 13 neurons across 4 animals, α=0.05, p=0.013, paired t-test).
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