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Identification of novel transcription factors and development of strategies for their modulation could lead to effective regeneration of pancreatic β-cells.
Therefore, a common goal in drug design, discovery and safety pharmacology is to obtain a compound with both high affinity for the protein of interest (target) and with high selectivity against other proteins for which activity modulation could lead to unwanted and possibly toxic events (off-targets) [1, 2].
In addition, any factor effecting the so-called up and down states or cortical excitability within the default network (including dopaminergic modulation) could lead to activational abnormalities; see (Haider et al. 2006, Vincent et al. 2006) for descriptions of up-down states.
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This likely reflects microenvironment modulation, which could lead proliferative leukemic cells, by an, as yet, unknown mechanism, to abandon protective microenvironment niches and thus induce them into apoptosis.
A better channel condition, for example, 64 quadrature amplitude modulations (QAM), could lead to higher throughput than a poor channel, for example, quadrature phase shift keying (QPSK) modulation scheme.
In conclusion modulation of PL signaling could lead to targeted therapies for acute brain injuries.
Further research on possible mechanisms of VALE- and OA-induced modulation of cell migration could lead to a better understanding of the therapeutic options regarding these triterpenes.
Small molecule binding and stabilization or modulation of these dynamic structures could lead to the development of therapeutic agents for their associated diseases.
We investigated whether inhibition of GSK3 could lead to a modulation of Maf target gene expression in HMCLs.
11 It would be interesting to investigate this further in Asian populations as distribution of HLA subtypes varies across races and it has been suggested that this could lead to differential modulation of the genetic effects of PADI4.
In the context of ROS, it is tempting to speculate that alterations in ROS could lead to selective modulation of glycolytic flux as has been suggested to occur with pyruvate kinase (Anastasiou et al., 2011).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com