Sentence examples for modulation by multiple from inspiring English sources

Integrated modulation by multiple peptides, as opposed to the highly organised structure of cortical systems, appears to be a general feature of the limbic system [58], so the recent attempts to apply systems biology methodologies to advance our understanding of the multivariate control of GnRH secretion are increasingly important [59].

However, such a seemingly simple pathway is subject to sophisticated modulation by multiple factors at multiple levels of signal transduction.

Such an approach might start with small, rapidly implemented and brief (60 days or less) translational clinical trials of biomarker modulation by multiple doses of a given intervention, alone or in combination with other mechanism-based agents.

Continuous systems integrating somatosensory, visual and vestibular sensory input are well represented by the spinal and transcortical reflexive pathways: these systems provide high-bandwidth feedback at short latency using feedback parameters which are preselected and open to modulation by multiple brain regions (Brooks 1986; Rothwell 1994; Pruszynski and Scott 2012).

A summary of case-control reports on the association of codon 72 polymorphism with breast cancer across the globe, including our results, revealed an inconsistency in association [ 26- 41], again pointing toward modulations by multiple factors (Additional File 2).

Of course, modulation of toxicological effects by multiple stressors is not only relevant for ecotoxicological aspects in urban areas but for all ecotoxicological studies that contain more than one individual as many external and internal factors may modulate the effects of a substance (Figure 1).

The high NDRG1 expression levels found in these reactive areas supports studies that have demonstrated its modulation during differentiation and by multiple stress-inducing agents.

These results provide powerful evidence for the chemopreventive efficacy of CH against chemically induced renal carcinogenesis possibly by modulation of multiple molecular pathways.

Therefore, trastuzumab could exert synergistic interaction with anti-VEGF monoclonal antibody to suppress tumor angiogenesis by modulation of multiple angiogenic factors.

However, understanding the mode of action of phenotypic screening hits can prove challenging since many drugs act by modulation of multiple intracellular targets ("network pharmacology") [9].

Thus, the generation and modulation of reactive oxygen species by multiple enzymes induced later in A. gambiae infection, which we now observe, may regulate or limit oocyst development.