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However, no information is available in relation to cancer mortality, other causes of death, and modulation by diet.
Our results are supported by studies in mice in which a modulation by diet on the association of the fto gene with glucose intolerance has been reported [ 32].
However, the FASN mRNA levels were similar across experimental groups and showed no correlation with the main liver fatty acids, thus suggesting no modulation by diet or silage level under these experimental conditions.
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We also examined modulation by Mediterranean diet (MedDiet) intervention (high in MUFA) on these associations.
Another hypothesis to explain gene expression modulation by hyperlipidic diets is related to nuclear receptors like peroxisome proliferator-activated receptors (PPARs), which act like transcription factors.
Thus, we hypothesized that modulation of animal performance by diet could be explained by modulation of the population of ruminal microorganisms.
The association of the TCF7L2- rs7903146 polymorphism with plasma lipids is controversial, and we found great variability in results depending on the different populations analyzed (26– 30), suggesting a possible modulation of this association by diet.
Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity.
The modulation of the gut microbiota by diet could be effective in improving the low-grade inflammation associated with obesity and related diseases [ 7, 8].
Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood.
Inter-individual variability in expression of drug-metabolizing enzymes (and transporters) is anticipated from the known genotypes but subsequent modulation by various factors (hormonal status, diet, environmental chemicals, etc).
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