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Evidently immune modulation appears to affect the speed and/or the extent of prion replication outside but not within the CNS.
Such specific downward modulation appears to be strengthened in a series of steps; the tuning shifts induced by cortical activation intensify as they progress from the cochlear nucleus to the auditory midbrain to the auditory thalamus [12], [15], [18], [32].
Thus, the TCA cycle acts both as a scavenger and generator of ROS and its modulation appears to be an important strategy in O2-dependent organisms to regulate the intracellular levels of ROS.
In rats dopaminergic modulation appears to play a role in altering odour discrimination [37] and dopamine has been shown to regulate other seasonally changing regions and behaviour in European starlings [38].
Indeed impedance modulation appears to be, to some extent, governed by preservation of metabolic cost [2] in that subjects do not just naively stiffen up their limbs but rather learn the optimal mechanical impedance by predictively controlling the magnitude, shape, and orientation of the endpoint stiffness in the direction of the instability.
One such modulation appears to be brought about by Nrd1 phosphorylation that is also influenced by the expression levels of Nab3 [20,186].
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This modulation appeared to be non-monotonic and showed a very complex concentration dependence pattern.
The inflammation-induced dynamic changes in descending modulation appeared to be correlated with changes in the activation of the N-methyl-d-aspartate (NMDA) excitatory amino acid receptor.
DOI: http://dx.doi.org/10.7554/eLife.10111.014 The observation that two types of Gαs-dependent modulappearappear to regulate synaptogenesis in d- and iSPNs raises the possibility that PKA activity, via Gαs GPCRs, generally serves to potentiate activity-dependent synaptogenesis during the time of rapid synapse production.
By contrast, the high gamma band modulations appeared to display a behavior largely contrasting with that of the lower bands.
A therapeutic strategy that combines rehabilitation training and pharmacological modulation of neurotransmitters appears to be a particularly promising approach to increasing recovery after longstanding injury.
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