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This improved theory of LO-refinement described from term (17) to term (25) can fully avoid the inference of non-target modules and account the effect of CTF modulation, and thereby would yield further improved reconstruction of the target modules, especially when dealing with the real experimental data.
Epigenetic editing of a single gene results in gene expression modulation, and thereby fully exploits the reversibility of epigenetic modifications as therapeutic targets while reducing off-target effects.
This signal appears to modulate the timing of the onset of visually evoked spiking activity during fixations, leading to a locking of these first spikes to a specific phase of the LFP modulation and thereby providing a mechanism for the synchronization of these spikes.
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The phenocopy phenomenon can be translated and used for drug discovery processes through inhibiting a drug target with different functional modulation technologies and thereby mimicking a phenotype of interest.
Novel allelic forms of same gene from different species resulting in differential modulation pattern and thereby effecting varied levels of stress tolerance will help to understand the biochemical and physiological mechanism that gets altered to overcome stressed conditions.
In conclusion, this study provides a plausible explanation of a previously unknown mechanism of agonist-induced heteromeric pairing and subsequent functional modulation of NMDAR-LBDs and thereby provides critical insights to answer the question as to why coagonism is required for NMDAR activation.
The regulation of laminin, TIMP1 and MMP9 by TNFα has been described [55] [59] and here our results show decreased expression of TIMP1 that together with the decreased laminin gamma 1 expression indicate towards a modulation of the extracellular matrix and thereby of cell adhesion within the hepatocyte by TNFα.
From our data, we infer that HUWE1-mediated ubiquitylation is an effective mechanism to achieve spatiotemporal modulation of TIAM1 protein levels and thereby regulate motility selectively.
In demonstrating state-dependent modulation of categorization in bees, and thereby a cognitive component of emotion, we show that the bees' response to a negatively valenced event has more in common with that of vertebrates than previously thought.
The accuracy and deliverability of VMAT treatment plans were found to be substantially increased by limiting the number of monitor units (MU) per beam at the optimization stage, and thereby limiting beam modulation complexity.
These zinc metalloenzymes catalyse a reversible conversion of carbon dioxide to bicarbonate and proton, and thereby contribute to modulation of ion transport and maintenance of acid-base balance.
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CEO of Professional Science Editing for Scientists @ prosciediting.com